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Several evidences have demonstrated that adult mammals could achieve a wide range of spontaneous sensory-motor recovery after spinal cord injury by means of various forms of neuroplasticity. In this study we evaluated the possibility that after low-thoracic spinal cord hemisection in the adult rat, significant hindlimb locomotor recovery could occur, and that this recovery may be driven, at least in part, by mechanisms of synaptic plasticity. In order to address these issues, we measured the expression levels of synapsin-I and brain-derived neurotrophic factor by Western blotting, at various time points after hemisection and correlated them with the motor performance on a grid walk test. Regression analysis showed that the expression of synapsin-I was strongly correlated with the spontaneous recovery of hindlimb locomotion (R = 0.78).Conversely, neither the expression levels of synapsin-I nor the locomotor …
Publication date: 
1 Jan 2007

Rosario Gulino, Massimo Dimartino, Antonino Casabona, Salvatore Andrea Lombardo, Vincenzo Perciavalle

Biblio References: 
Volume: 57 Issue: 1 Pages: 148-156
Neuroscience research