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Conventional approaches to human intracellular optical sensing, generally, require dedicated laboratories with bulky detection systems. They are performed by cell labeling procedures based on the use of fluorophores that are, mostly, phototoxic, invasive, bleached in case of prolonged light exposures, which require carriers and/or structural modifications for the cellular uptake. These issues, together with the sensitivity of the eukaryotic cell model, could be problematic towards the development of a robust sensing system suitable for biomedical screening. In this work, we studied a sensing system resulting from the combination of the commercial tris (2, 2’bipyridyl) ruthenium (II) fluorophore, for cell labeling, with a potentially miniaturizable optical system composed by a laser source and a photomultiplier tube, for the fluorescence analysis. View Full-Text
Multidisciplinary Digital Publishing Institute
Publication date: 
1 Jan 2019

Emanuele Luigi Sciuto, Giusy Villaggio, Maria Francesca Santangelo, Samuele Laudani, Concetta Federico, Salvatore Saccone, Fulvia Sinatra, Sebania Libertino

Biblio References: 
Volume: 9 Issue: 5 Pages: 975
Applied Sciences