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Type: 
Journal
Description: 
In this paper, silicon photomultipliers (SiPM) are proposed as optical detectors for bio sensing. Optical transduction is the most used detection mechanism in many biosensor applications, such as DNA microarray and real-time polymerase chain reaction. The performances of a 25 pixels device used for both applications are studied. The results confirm that the SiPM is more sensitive than the traditionally employed detectors. In fact, it is able to experimentally detect 1 nM and 100 fM of fluorophore concentrations in dried samples and solutions, respectively. We present and discuss in details the detector configuration and its characterization as fluorescence detector for bio sensing.
Publisher: 
Publication date: 
1 Jan 2016
Authors: 

Alessandro Busacca, Maria Francesca Santangelo, Sabrina Conoci, Sebania Libertino, Salvatore Petralia, Salvatore A Lombardo, Emanuele Luigi Sciuto

Biblio References: 
Volume: 22
Origin: 
IEEE JOURNAL OF SELECTED TOPICS IN QUANTUM ELECTRONICS